Licorice Side Effects: Risks, Safety, and Precautions

By Maya Richardson

January 4, 2026

Licorice is a familiar ingredient in herbal remedies and food, yet it also elicits subtle biological responses in the body. Behind its mild sweetness lies a chain of effects related to blood pressure, electrolytes, and hormones.

These changes occur subtly, then manifest through feelings of energy, circadian rhythms, and daily physical state. Understanding this aspect of licorice opens up a more insightful perspective on how the body responds to this common medicinal herb.

licorice-side-effects

Licorice can cause side effects, but it is safe when used responsibly and mindfully.

What Licorice Side Effects Are Common

Licorice offers many biological benefits, but it can also cause noticeable side effects when used frequently or at high doses. Early identification of common symptoms helps users proactively adjust and use it more safely in their daily lives.

Fluid Retention and Swelling

Licorice stimulates the body to retain sodium and water, leading to a feeling of heaviness. Mild swelling in the face, hands, or ankles is more pronounced in the morning. The body signals a change in intracellular fluid balance.

Blood Pressure Elevation

The active ingredient glycyrrhizin directly affects the renin-angiotensin system. Blood pressure gradually increases with use. Heart rate becomes more pronounced, and a feeling of tension in the head appears in some sensitive individuals.

Muscle Weakness and Fatigue

Electrolyte changes, especially potassium, affect muscle and nerve function. Users may experience muscle fatigue, reduced stamina, and general lethargy despite normal activities. These are notable physiological signs of prolonged licorice use.

Effects on Blood Pressure

Licorice produces a significant physiological effect on blood pressure through endocrine and electrolyte mechanisms. With regular use, the body responds by regulating the vascular system and circulating volume. Early awareness of these effects helps users maintain safety during use.

Glycyrrhizin and Vascular Response

Glycyrrhizin activates sodium retention in the kidneys and increases circulating blood volume. Intravascular pressure increases in accordance with the natural circadian rhythm. The vessel walls respond by gently constricting, allowing a gradual increase in blood pressure.

Cumulative Blood Pressure Changes

Blood pressure clearly reflects the cumulative effect of licorice with prolonged use. Systolic pressure gradually increases, and feelings of head tension and chest heaviness become more pronounced. The body continuously signals adaptation, highlighting the crucial role of controlling dosage and duration of use.

Electrolyte Imbalance Risks

Licorice directly affects the electrolyte balance system, especially when used regularly over a long period. These physiological changes occur subtly, then manifest clearly through bodily sensations. Early identification helps users proactively adjust their usage safely.

Potassium Depletion

Licorice promotes the excretion of potassium through the kidneys. Decreased potassium levels affect nerve transmission and muscle contraction. The body exhibits muscle fatigue, weakness, and reduced concentration in daily activities.

Sodium and Fluid Retention

The active ingredient glycyrrhizin increases sodium retention in the body. Extracellular fluid volume increases, creating a feeling of fullness and tightness. The circulatory system reacts clearly to this change.

Neuromuscular Signals

Electrolyte imbalance directly impacts the neuromuscular system. Mild numbness, muscle tremors, or fatigue appear as warning biological signals. The body communicates its need for adjustment through these expressions.

Drug Interactions to Watch For

Licorice exhibits strong biological activity; therefore, drug interactions become a factor to be considered during use. When combined with certain medications, the body responds in a clear, predictable way. Understanding the related drug groups helps maintain treatment safety.

Blood Pressure Medications

Licorice directly affects the mechanism of blood pressure regulation. When used with cardiovascular medications, the physiological response of blood vessels becomes more pronounced. Blood pressure continuously reflects this change.

Diuretics and Electrolyte Balance

Diuretics strongly affect sodium and potassium. Licorice amplifies the electrolyte effect in the body. The neuromuscular system transmits adaptive signals through feelings of fatigue and reduced energy.

Corticosteroids

Licorice affects cortisol metabolism. When combined with corticosteroids, the endocrine response becomes more sensitive. The body adjusts hormone levels to enhance the biological response.

Heart Rhythm Medications

Potassium levels affect heart rate. Licorice increases the sensitivity of the cardiac conduction system. Heart rate clearly reflects physiological adaptations in daily life.

Hormonal and Adrenal Concerns

Licorice has a profound impact on the endocrine axis, particularly the adrenal glands and stress hormones. These effects occur through clear biological mechanisms, directly reflected in perceived energy levels, mood, and daily routines. Proper understanding allows users to proactively adjust their usage habits.

Cortisol Regulation Effects

Glycyrrhizin prolongs cortisol's activity in the blood. This hormone maintains alertness and a higher stress response. The body exhibits changes, including increased energy, a more pronounced circadian rhythm, and a faster response to environmental stimuli.

Adrenal Gland Stimulation

The adrenal glands respond positively to licorice's active ingredients. This stimulation affects overall hormonal balance. Users clearly perceive changes in endurance, stress tolerance, and overall physiological state in their daily lives.

Digestive Reactions

Licorice interacts directly with the digestive system through its biological activity on the mucosa and intestinal motility. These reactions often appear early, reflecting how the body receives and processes the herb in daily life. Correct understanding helps users adjust the dosage to suit their physical condition.

Gastric Sensation Changes

Licorice stimulates the secretion of digestive juices and increases the feeling of warmth in the epigastric region. The stomach responds with a feeling of mild fullness or gnawing. The digestive system clearly shows physiological adaptation in a short time.

Bowel Movement Response

The active compounds in licorice affect intestinal motility. The digestive process is faster and more pronounced. The body reflects this through changes in bowel rhythm and a feeling of constant abdominal activity.

Taste and Appetite Signals

Licorice imparts a characteristic sweet taste that alters the eating experience. Taste becomes more pronounced during meals. The digestive center responds with increased appetite signals and heightened taste perception.

Sensitive Populations

Licorice has a strong biological effect, so some people show more pronounced reactions when using it. Identifying sensitive populations helps control licorice use, tailoring it to individual health conditions and needs.

Pregnant and Breastfeeding Women

The endocrine activity of licorice affects the natural hormonal balance. Pregnant and breastfeeding women's bodies react quickly to these changes. Their circadian rhythms and energy levels clearly demonstrate physiological sensitivity.

People with Hypertension

Licorice directly impacts blood pressure and circulating volume. People with high blood pressure clearly feel the changes in their bodies. The cardiovascular system reflects this through heart rate and a feeling of fullness in the veins.

Individuals with Kidney Conditions

The kidneys play a central role in electrolyte regulation. Licorice increases the physiological regulatory burden on this organ. The body signals adaptation through feelings of fatigue and changes in fluid balance.

Older Adults

Metabolism slows down with age. Licorice produces a longer-lasting biological response in older adults. The body clearly demonstrates this sensitivity through daily energy and endurance.

Safe Dosage and Duration Guidelines

Licorice is most effective when dosage and duration are carefully controlled. The body responds very well to regular and purposeful use. Understanding safety principles helps licorice consistently exert its biological value.

Recommended Intake Awareness

The appropriate licorice dose depends on the form of use and individual health. The body adapts better to moderate amounts. Physiological signals, such as energy levels, blood pressure, and digestion, reflect this adaptation.

Duration Matters

The duration of use directly affects endocrine and electrolyte responses. Licorice shows a more pronounced effect when used in short cycles. The body maintains better balance with a time-limited approach.

Individual Sensitivity Consideration

Each person has a different level of biological sensitivity. Licorice is most effective when adjusted according to individual perception. Listening to your body helps maintain long-term safety during use.

Signs You Should Stop Taking Licorice

The body always sends clear signals when licorice produces a physiological response that exceeds the body's tolerance threshold. Early recognition of these signs helps users proactively stop at the right time, thereby protecting homeostasis and overall health.

Notifiable Swelling and Weight Changes

Mild swelling in the face, hands, or ankles occurs along with a feeling of heaviness. A short-term increase in body weight reflects changes in fluid and electrolytes. This is a biological signal that needs immediate attention.

Persistent Fatigue or Muscle Symptoms

The body exhibits persistent fatigue, muscle weakness, or a feeling of lethargy despite normal activities. The neuromuscular system sends clear messages about internal imbalance. Stopping licorice use at this point helps the body quickly return to a stable state.

Conclusion

Licorice offers clear medicinal value when used with understanding and proactiveness. The body responds transparently through blood pressure, electrolytes, hormones, and daily physiological sensations. Gentle medical awareness helps users better observe these signals.

Respecting dosage, timing, and individual physical condition forms the foundation for long-term safety. Licorice delivers sustainable benefits when used mindfully, with mindful listening to the body and responsible choices.

FAQs – Licorice Side Effects and Safe Daily Use

Frequently Asked Questions (FAQs)

  • Does licorice cause side effects when used daily? – Daily use of licorice can lead to cumulative biological effects. These may involve blood pressure, electrolyte levels, and energy balance, making self-monitoring essential for safe use.
  • What signs indicate a strong reaction to licorice? – Symptoms such as mild swelling, fatigue, muscle weakness, or blood pressure changes signal that the body is reacting strongly and that intake should be adjusted.
  • Does licorice affect hormones? – Licorice influences cortisol and the broader endocrine system. These hormonal effects can impact energy patterns and daily rhythms, highlighting the need for controlled use.
  • Who needs to be more cautious when using licorice? – Pregnant women, people with hypertension or kidney disease, and older adults often show increased sensitivity. Careful attention to dose and duration is especially important for these groups.
  • How can licorice be used safely long-term? – Using licorice safely over time involves moderate dosing, periodic breaks, and listening closely to bodily feedback. A mindful, proactive approach helps maintain long-term physiological balance.
Article by

Maya Richardson

Maya overflows with a passion for writing and researching health. Her deep love of words and her endless curiosity helps Maya to empower those around her with invaluable information about a healthier lifestyle.

Latest Posts

Poppy Seeds Benefits: Rich in Minerals, Antioxidants, and Healthy Fats
What Is Cinnamon Good For? Health Benefits You Should Know
Marshmallow Root: Soothing Herb for Digestive and Respiratory Health
Is Green Tea Good for You? Health Benefits Revealed